New paper about a key regulator of missing-self innate immunity is now published online in Molecular Biology and Evolution

In this study, Rocco F. Notarnicola et al. (2026, https://doi.org/10.1093/molbev/msag082) show how an innate immune regulator (CFH), thought to be conserved  due its interactions with self-components, is instead very polymorphic and under diversifying selection, likely due to pathogen exploitation (e.g. Borrelia). Indeed, CFH sites involved in interactions with pathogens were under positive selection across rodents. This research was funded by NCN grant 2019/34/A/NZ8/00231 to Jacek Radwan.